MK-677 (Ibutamoren)

The Oral Growth Hormone Secretagogue

Also known as: Ibutamoren Mesylate, MK-0677, L-163,191, Oratrope, LUM-201

CAS Number: 159752-10-0

Why Researchers Choose MK-677 Peptide

Unlike injectable growth hormone or peptide-based secretagogues that require frequent use, MK-677 is an orally active compound with a 24-hour half-life that maintains the body’s natural pulsatile growth hormone release patterns. This makes it uniquely valuable for long-term studies examining GH/IGF-1 axis modulation without the complications of injections or the suppression of endogenous hormone production that occurs with exogenous GH administration.

What It Is

MK-677 is a synthetic, non-peptide ghrelin receptor agonist—essentially a molecule that mimics the hunger hormone ghrelin’s effects on growth hormone secretion. Despite being classified alongside growth hormone releasing peptides, it’s technically not a peptide at all but rather a spiropiperidine compound that researchers became interested in when early studies demonstrated it could stimulate robust GH and IGF-1 increases through oral administration, something most growth hormone modulators cannot accomplish effectively.

How It Works (What Makes It Interesting)

Studies suggest MK-677 influences the GH/IGF-1 axis through several mechanisms:

• Ghrelin Receptor Activation – Binds to GHS-R1a receptors in the hypothalamus and pituitary gland, triggering the same signaling cascade that natural ghrelin uses to stimulate growth hormone release
• Pulsatile GH Secretion – Increases both the amplitude and frequency of natural GH pulses by up to 97% above baseline, while maintaining the body’s circadian rhythm and feedback mechanisms that prevent hormonal shutdown
• IGF-1 Elevation – Raises serum IGF-1 levels by 40-60% through sustained GH stimulation, which mediates downstream anabolic effects on muscle, bone, and metabolic tissues
• Selective Receptor Activity – Does not significantly increase cortisol levels (unlike some GH secretagogues), allowing researchers to isolate GH/IGF-1 effects without the confounding variable of elevated stress hormones
• Bone Turnover Stimulation – Increases markers of both bone formation (osteocalcin, bone-specific alkaline phosphatase) and resorption (N-telopeptide cross-links), providing insight into dynamic bone remodeling processes

Common Research Applications

Age-Related Sarcopenia Studies: Muscle mass loss in elderly populations, frailty syndrome research, functional impairment models, fat-free mass preservation during aging

Bone Health & Osteoporosis Research: Postmenopausal bone loss, bone mineral density studies, hip fracture recovery models, bone turnover marker analysis, osteopenia research

Growth Hormone Deficiency Models: Pediatric GH deficiency, adult-onset GH deficiency, comparative efficacy vs injectable recombinant GH, oral GH secretagogue alternatives

Metabolic & Catabolic Research: Diet-induced nitrogen wasting, caloric restriction studies, obesity models, lean body mass preservation, insulin sensitivity and glucose metabolism

Sleep Quality Research: REM sleep enhancement studies, slow-wave sleep analysis, sleep architecture in aging populations, sleep-dependent memory consolidation

Neurological Research: Alzheimer’s disease models (amyloid-beta clearance), cognitive function in elderly subjects, neuroprotection studies, IGF-1-mediated brain effects

Body Composition Studies: Fat-free mass quantification, visceral fat distribution, appendicular skeletal muscle mass, comparative body composition methodologies

What You’re Getting

Every batch of our MK-677 meets rigorous research standards:

• Exceeds 99% Purity – Verified by HPLC analysis
• Certificate of Analysis (COA) – Included with every order, showing purity and identity confirmation
• Endotoxin-Free – Tested to ensure <1 EU/mg for cell culture applications
• Manufactured in USA – GMP-certified facilities with full traceability
• Sterile & Lyophilized – Stable for long-term storage, easy reconstitution
• Fast Shipping – Most orders ship same day. We offer flat rate shipping and 2-3 day delivery in the USA

Click the “Add To Cart” button to grab your MK-677 today!

Research Use Only

This product is intended strictly for laboratory research purposes. Not for human consumption, clinical use, veterinary applications, or any diagnostic or therapeutic purposes.

Important Regulatory Context: MK-677 is classified as an Investigational New Drug (IND) by the FDA and is not approved for human use. It is prohibited by the World Anti-Doping Agency (WADA) and appears on the DoD Prohibited DS Ingredients List. Clinical trials have noted potential concerns including insulin resistance, edema, and cardiovascular risks in certain populations. Long-term safety in healthy subjects has not been established. This compound should only be used in controlled laboratory research settings by qualified researchers.